河豚毒素TETRODOTOXIN ( TTX )钠离子通道阻断剂 Molecular Formula : C11H17N3O8 from Fugu Fish organs Molecular Weight : 319.28 Chemical Name : Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino [6,5-d]pyrimidinepentol * Melting Point : does not melt at 200°C, darkens and black with increasing temperature. * Solubility in : dilute acetic acid, dilute sulfuric acid, ethanol, or citrate buffer ( pH 4.8-4.9 ); slightly in water, dry alcohol and ether; insoluble in organic solvent. * Purity min. : 99% ( HPLC, TLC-FID, IR, NMR ). * Physical Form : white crystal powder. Physical Form : white crystal powder. * Biological Activity : KD ( cardiac myocytes in rats ) : 0.8 nM(2) * 10-8 M block nervous system; * 10-5 M block heart muscle. The binding to Na+ channel is reversible. ED50 = 3.7 nM. * Toxicity ( LD50 ) : 　mice ( i.v.) : 8.4 mg / kg. ; 　mice ( i.p.) : 8.1 mg / kg. ; mice ( s.c.) : 10.8 mg / kg. * Storage recommendations : stable at room temperature, store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity. Solution for use: reconstitute in citrate or acetate buffer, pH 4.8-4.9 . Safety recommendations: highly toxic. * CAS Reg. No. : 质量保证，欢迎索取详细资料，咨询洽谈。 北京普华仕科技发展有限公司 在线QQ客服：、 电话： 手机：