黄芩素 Baicalein
Lipoxygenase inhibitor
Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes.
PRODUCT PROPERTIES
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Alternative Name: |
5,6,7-Trihydroxyflavone |
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MI: |
14: 942 |
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Solubility: |
Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water. |
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Long Term Storage: |
-20°C |
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Use/Stability: |
Subject to oxidation. |
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Hazard: |
IRRITANT. |
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Handling: |
Protect from light. |
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MW: |
270.2 |
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CAS: |
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Formula: |
C15H10O5 |
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Purity: |
≥98% (TLC) |
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Appearance: |
Yellow to yellow-green crystalline powder. |
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