毛壳素Chaetocin
Methyltransferase inhibitor
Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
PRODUCT PROPERTIES
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Source/Host: |
Isolated from Chaetomium sp- |
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Solubility: |
Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide or methanol. Poorly souble in water. |
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Long Term Storage: |
-20°C |
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Use/Stability: |
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Hazard: |
HARMFUL. |
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MW: |
696.9 |
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CAS: |
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Formula: |
C30H28N6O6S4 |
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Purity: |
≥ 98% (TLC) |
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Appearance: |
White to off-white solid. |
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