河豚毒素TETRODOTOXIN(TTX)

河豚毒素 TETRODOTOXIN (TTX) 

 

Molecular Formula :C11H17N3O8    

Molecular Weight : 319.28

CAS No:  

Chemical Name : 

Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-\[1,3]dioxocino 

\[6,5-d]pyrimidinepentol  

Melting Point : 

does not melt at 200--C, darkens and black with increasing temperature. 

Solubility in : 

dilute acetic acid, dilute sulfuric acid, ethanol, or citrate buffer ( pH 4.8-4.9 ); 

slightly in water, dry alcohol and ether; insoluble in organic solvent. 

Purity min. : 

99% ( HPLC, TLC-FID, IR, NMR ).

Physical Form : 

white crystal powder. 

Biological Activity : 

KD( cardiac myocytes in rats ) :0.8 nM(2)10-8 M block nervous system; * 10-5 M block heart muscle. The binding to Na+ channel  is  reversible.   

ED50 = 3.7 nM. 

Toxicity 

( LD50) : mice ( i.v.) : 8.4 mg / kg. ;  

mice ( i.p.) : 8.1 mg / kg. ; 

mice ( s.c.) : 10.8 mg / kg. 

Storage recommendations :  

stable at room temperature, store preferably at 

4C. Solid and solutions  can be kept in deep 

freeze for a long time without any change in their activity. Solution for use: reconstitute   in 

citrate or acetate buffer, pH 4.8-4.9 .  Safety recommendations: highly toxic. 

Merck Index 12th Ed. : 9382