Adverse effects on human health and the environment from substances of very high
concern should be prevented through the application of appropriate risk management
measures to ensure that any risks from the uses of a substance are adequately controlled,
and with a view to progressively substituting these substances with a suitable safer
substance. Risk management measures should be applied to ensure, when substances are
manufactured, placed on the market and used, that exposure to these substances including
discharges, emissions and losses, throughout the whole life-cycle is below the threshold
level beyond which adverse effects may occur. For any substance for which authorisation
has been granted, and for any other substance for which it is not possible to establish a safe
level of exposure, measures should always be taken to minimise, as far as technically and
practically possible, exposure and emissions with a view to minimising the likelihood of
adverse effects. Measures to ensure adequate control should be identified in any Chemical
Safety Report. These measures should be applied and, where appropriate, recommended to
other actors down the supply chain.
